کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5041328 | 1474014 | 2017 | 6 صفحه PDF | دانلود رایگان |
- A left-handed woman became aphasic following right hemisphere MCA stroke.
- During recovery there was a loss in RH and gain in LH ROIs supporting processing.
- During recovery more ROI dynamics drove LH ROIs, and fewer drove RH ROIs.
- The resultant network was more left-lateralized than that of right-handed controls.
In this paper we demonstrate the application of new effective connectivity analyses to characterize changing patterns of task-related directed interaction in large (25-55 node) cortical networks following the onset of aphasia. The subject was a left-handed woman who became aphasic following a right-hemisphere stroke. She was tested on an auditory word-picture verification task administered one and seven months after the onset of aphasia. MEG/EEG and anatomical MRI data were used to create high spatiotemporal resolution estimates of task-related cortical activity. Effective connectivity analyses of those data showed a reduction of bilateral network influences on preserved right-hemisphere structures, and an increase in intra-hemispheric left-hemisphere influences. She developed a connectivity pattern that was more left lateralized than that of right-handed control subjects. Her emergent left hemisphere network showed a combination of increased functional subdivision of perisylvian language areas and recruitment of medial structures.
Journal: Brain and Language - Volume 170, July 2017, Pages 12-17