کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5043371 | 1475137 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Basolateral amygdalar D2 receptor activation is required for the companions-exerted suppressive effect on the cocaine conditioning Basolateral amygdalar D2 receptor activation is required for the companions-exerted suppressive effect on the cocaine conditioning](/preview/png/5043371.png)
- The intactness of BLA is required for the companions-exerted suppressive effect on the cocaine-induced CPP.
- Activation of D2 receptor in the BLA is required for the companions-exerted suppressive effect on the CPP.
- The presence of wooden blocks in the cocaine conditioning may not produce suppressive effect on the cocaine-induced CPP.
The presence of companions renders decreases in cocaine-stimulated dopamine release in the nucleus accumbens and cocaine-induced conditioned place preference (CPP) magnitude. Limbic systems are widely believed to underlie the modulation of accumbal dopamine release and cocaine conditioning. Thus, this study aimed to assess whether intact basolateral nucleus of amygdala (BLA), dorsal hippocampus (DH), and dorsolateral striatum (DLS) is required for the companions-exerted suppressive effect on the cocaine-induced CPP. Three cage mates, serving as companions, were arranged to house with the experimental mice in the cocaine conditioning compartment throughout the cocaine conditioning sessions. Approximately 1Â week before the conditioning procedure, intracranial ibotenic acid infusions were done in an attempt to cause excitotoxic lesions targeting bilateral BLA, DH and DLS. Albeit their BLA, DH, and DLS lesions, the lesioned mice exhibited comparable cocaine-induced CPP magnitudes compared to the intact and sham lesion controls. Bilateral BLA, but not DH or DLS, lesions abolished the companions-exerted suppressive effect on the cocaine-induced CPP. Intact mice receiving intra-BLA infusion of raclopride, a selective D2 antagonist, 30Â min prior to the cocaine conditioning did not exhibit the companions-exerted suppressive effect on the cocaine-induced CPP. Intra-BLA infusion of Sch23390, a selective D1 antagonist, did not affect the companions-exerted suppressive effect on the CPP. These results, taken together, prompt us to conclude that the intactness of BLA is required for the companions-exerted suppressive effect on the cocaine-induced CPP. Importantly, activation of D2 receptor in the BLA is required for such suppressive effect on the CPP.
Journal: Neurobiology of Learning and Memory - Volume 137, January 2017, Pages 48-55