کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5043772 1475299 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pretreatment and prophylaxis against nerve agent poisoning: Are undesirable behavioral side effects unavoidable?
ترجمه فارسی عنوان
پیشگیری و پیشگیری از مسمومیت عصبی: آیا عوارض جانبی رفتاری ناخواسته اجتناب ناپذیر است؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Pretreatment with pyridostigmine reduces lethality of nerve agent poisoning.
- Behavioral side effects of pyridostigmine are not consistently produced in animals.
- Prophylactic treatment generally results in severe behavioral side effects in animals.
- Use of bioscavengers may solve the problem with behavioral side effects.

The threat of chemical warfare agents like nerve agents requires life saving measures of medical pretreatment combined with treatment after exposure. Pretreatment (pyridostigmine) may cause some side effects in a small number of individuals. A comprehensive research on animals has been performed to clarify effects on behavior. The results from these studies are far from unambiguous, since pyridostigmine may produce adverse effects on behavior in animals in relatively high doses, but not in a consistent way. Other animal studies have examined the potential of drugs like physostigmine, galantamine, benactyzine, trihexyphenidyl, and procyclidine, but they all produce marked behavioral impairment at doses sufficient to contribute to protection against a convulsant dose of soman. Attempts have also been made to develop a combination of drugs capable of assuring full protection (prophylaxis) against nerve agents. However, common to all combinations is that they at anticonvulsant doses cause behavioral deficits. Therefore, the use of limited pretreatment doses may be performed without marked side effects followed by post-exposure therapy with a combination of drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 71, December 2016, Pages 657-670
نویسندگان
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