کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5043778 | 1475299 | 2016 | 17 صفحه PDF | دانلود رایگان |
- Examine cortico-thalamo-striatal and cerebellar contributions to sub- and super-second timing.
- Identify aspects of cerebellar and striatal architecture relevant to timing.
- Discuss role of degeneracy for timing within distributed neural networks.
- Propose an integrative model of cerebellar/striatal timing with distinct phases of temporal processing.
The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100-2000Â ms. For intervals in the supra-second range (e.g., >2000Â ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where cortico-thalamic-striatal circuits supporting higher-level cognitive functions take over. Moreover, the importance of intrinsic circuit dynamics as well as behavioral, neuroimaging, and lesion studies of the cerebellum and striatum are discussed in terms of a framework positing initiation, continuation, adjustment, and termination phases of temporal processing.
Journal: Neuroscience & Biobehavioral Reviews - Volume 71, December 2016, Pages 739-755