کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5045063 1475555 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective verbal recognition memory impairments are associated with atrophy of the language network in non-semantic variants of primary progressive aphasia
ترجمه فارسی عنوان
اختلالات یادگیری انتخابی کلامی با آتروفی زبان شبکه در انواع غیر معنایی آپایسی پیشرونده اولیه همراه است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Recognition memory of auditory words is impaired in non-semantic PPA.
- Atrophy of left inferior frontal gyrus correlated with auditory word false alarms.
- Processing verbal stimuli can hinder episodic memory in PPA.
- Correlations provide evidence for distinct roles of the left and right temporal pole.

Primary progressive aphasia (PPA) is clinically defined by an initial loss of language function and preservation of other cognitive abilities, including episodic memory. While PPA primarily affects the left-lateralized perisylvian language network, some clinical neuropsychological tests suggest concurrent initial memory loss. The goal of this study was to test recognition memory of objects and words in the visual and auditory modality to separate language-processing impairments from retentive memory in PPA. Individuals with non-semantic PPA had longer reaction times and higher false alarms for auditory word stimuli compared to visual object stimuli. Moreover, false alarms for auditory word recognition memory were related to cortical thickness within the left inferior frontal gyrus and left temporal pole, while false alarms for visual object recognition memory was related to cortical thickness within the right-temporal pole. This pattern of results suggests that specific vulnerability in processing verbal stimuli can hinder episodic memory in PPA, and provides evidence for differential contributions of the left and right temporal poles in word and object recognition memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 100, June 2017, Pages 10-17
نویسندگان
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