کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
50495 | 46797 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Directed evolution of Candida antarctica lipase B for kinetic resolution of profen esters
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• Candida antarctica lipase B was subjected to directed evolution by CAST and ISM.
• Mutants showed increased activity and selectivity toward three profen esters.
• High enantioselectivity for flurbiprofen and ketoprofen esters was obtained.
The lipase B from Candida antarctica was subjected to directed evolution suggested by its structure. Mutants of the lipase show significantly increased activity and enantioselectivity toward profen esters compared to the wild type, especially for flurbiprofen ester (ee = 93%, E = 37) and ketoprofen ester (ee = 99%, E > 200).
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Catalysis Communications - Volume 38, 5 August 2013, Pages 1–5
Journal: Catalysis Communications - Volume 38, 5 August 2013, Pages 1–5
نویسندگان
Bin Qin, Ping Liang, Xian Jia, Xin Zhang, Mao Mu, Xiao-Ying Wang, Guo-Zhen Ma, Dan-Ni Jin, Song You,