Efficient and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones using imidazol-1-yl-acetic acid as a novel, reusable and water-soluble organocatalyst

A practical and green chemistry route to the Biginelli multicomponent cyclocondensation reaction using imidazol-1-yl-acetic acid as a novel bifunctional and efficient organocatalyst is described under two different sets of reaction conditions.

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► Imidazol-1-yl-acetic acid was used as a new organocatalyst for the Biginelli reaction.
► The reaction conditions are mild and eco-friendly.
► This organocatalyst is efficient, green and reusable.