کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5103337 1480104 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autoantibody recognition mechanisms of MUC1
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
پیش نمایش صفحه اول مقاله
Autoantibody recognition mechanisms of MUC1
چکیده انگلیسی
The most cost-effective blood-based, noninvasive molecular early cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities of order 50%. We explain the experimental observation that glycosylation does not enhance, and can depress, the sensitivity of MUC1 tandem repeat biomarkers. We propose a possible supplementary MUC1 epitope in the SEA region outside the tandem repeats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 469, 1 March 2017, Pages 244-249
نویسندگان
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