کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5119701 1485968 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantifying the contribution of alcohol to cardiomyopathy: A systematic review
ترجمه فارسی عنوان
کمک کردن مشارکت الکل در کاردیومیوپاتی: یک مرور نظام مند
کلمات کلیدی
کاردیومیوپاتی، الکل، الگوهای نوشیدن، پاسخ دز، جمعیت کسری اختصاصی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- Alcohol is a known toxin for the heart.
- However, to date, the impact on alcohol on cardiomyopathy has not yet been quantified.
- For this quantification, dose-response relationships are needed.
- There was not enough epidemiological evidence for a meta-analysis.
- Heavy drinking over several years was linked to high risk of cardiomyopathy.

Alcohol has a direct toxic impact on the heart, and while there is an ICD code for alcoholic cardiomyopathy, the burden of alcohol-attributable cardiomyopathy is not clear. For the usual estimation of this burden via population-attributable fractions, one would need to determine the risk relationships, i.e., average risk associated with different dimensions of alcohol exposure. The most important among these risk relationships is the dose-response relationship with different levels of average alcohol consumption. To establish risk relationships, we systematically searched for all studies on dose-response relationships, directly and indirectly, via reviews. The results did not permit computation of pooled estimates through meta-analyses. There were clear indications that heavy drinking (≥80 g per day) over several years was linked to high risk of cardiomyopathy, with greater lifetime exposure of alcohol linked to higher risks. Some studies indicated potential effects of patterns of drinking as well. As such, the global quantification of alcohol-attributable cardiomyopathy will have to rely on other methods than those used conventionally.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 61, June 2017, Pages 9-15
نویسندگان
, , , ,