کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5131936 1378783 2017 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical applications of MALDI imaging technologies in cancer and neurodegenerative diseases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Clinical applications of MALDI imaging technologies in cancer and neurodegenerative diseases
چکیده انگلیسی


- MALDI-IMS enables the correlation of molecular signatures with histology
- MALDI-IMS applications play an important role in preclinical and clinical research
- Literature review on MALDI-IMS applications in major cancer types and neurodegenerative diseases was conducted

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) enables localization of analytes of interest along with histology. More specifically, MALDI-IMS identifies the distributions of proteins, peptides, small molecules, lipids, and drugs and their metabolites in tissues, with high spatial resolution. This unique capacity to directly analyze tissue samples without the need for lengthy sample preparation reduces technical variability and renders MALDI-IMS ideal for the identification of potential diagnostic and prognostic biomarkers and disease gradation. MALDI-IMS has evolved rapidly over the last decade and has been successfully used in both medical and basic research by scientists worldwide. In this review, we explore the clinical applications of MALDI-IMS, focusing on the major cancer types and neurodegenerative diseases. In particular, we re-emphasize the diagnostic potential of IMS and the challenges that must be confronted when conducting MALDI-IMS in clinical settings. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1865, Issue 7, July 2017, Pages 795-816
نویسندگان
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