Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization

- A database of bioactive peptides was created from hundreds of published articles.
- Peptide mapping displays location and count of peptides within parent protein sequences.
- Homology search across species revealed 1061 potential functional milk peptides.
- The database enables bioactive peptide identification from peptidomics data.
- The database will serve as the basis for peptide function prediction modelling.

During processing and digestion, milk proteins are disassembled into peptides with an array of biological functions, including antimicrobial, angiotensin-converting enzyme inhibition, antioxidant, opioid, and immunomodulation. These functions are summarized in numerous reviews, yet information on which peptides have which functions remains scattered across hundreds of research articles. We systematically searched the literature for all instances of bioactive peptides derived from milk proteins from any mammalian source. The data were compiled into a comprehensive database, which can be used to search for specific functions, peptides, or proteins (http://mbpdb.nws.oregonstate.edu). To review this large dataset, the bioactive peptides reported in the literature were visually mapped on the parent protein sequences, providing information on sites with highest abundance of bioactive peptides.