First report on isolation of 2,3,4-trihydroxy-5-methylacetophenone from palmyra palm (Borassus flabellifer Linn.) syrup, its antioxidant and antimicrobial properties

- First report on 2,3,4-trihydroxy-5-methylacetophenone (1), nicotinamide (2), and uracil (3) in palmyra palm syrup.
- Total phenolic content and total flavonoid content of palymyra palm syrup.
- DPPH radical scavenging activity of compound 1.
- Broad spectrum antibacterial property of compound 1.

The first report on isolation and characterization of 2,3,4-trihydroxy-5-methylacetophenone (1), nicotinamide (2), and uracil (3) from palmyra palm syrup is described. Total phenolic content (TPC) and Total flavonoid content (TFC) of palm syrup were 244.70 ± 5.77 (mg gallic acid/kg of syrup) and 658.45 ± 27.86 (mg quercetin/kg of syrup), respectively. Compound 1 exhibited DPPH radical scavenging activity with an IC50 value of 20.02 ± 0.14 μM which was better than ascorbic acid (IC50 = 22.59 ± 0.30 μM). Compound 1 also showed broad spectrum antibacterial activity against Escherichia coli, Mycobacterium smegmatis, Staphylococcus aureus and Staphylococcus simulans.