A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers

- Review of HPLC-MS/MS methods for quantitation of anticancer drugs in urine.
- Includes drugs, isomers, drug metabolites and simultaneous multi-drug determinations.
- Tabular summaries of method sample preparation, LC parameters, and MS detection modes.
- Presents comparative overview of methods, their development, and validation protocols.
- Discussion of future trends including UHPLC-MS/MS and simultaneous multi-drug methods.

This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research.