کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137250 | 1494531 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice](/preview/png/5137250.png)
چکیده انگلیسی
The protective effects of L. plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L. plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L. plantarum C88 was also found to suppress the content of malondialdehyde (MDA) and enhance the activity of superoxide dismutase (SOD) in the liver, which are well-correlated with the downregulation of hepatic cytochrome P450 2E1 and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, L. plantarum C88 significantly abrogated the increased serum levels of TNF-α, IL-6, and IFN-γ induced by ethanol. L. plantarum C88 ameliorated gut leakiness by upregulating the expressions of tight junction proteins and suppressed the endotoxin-mediated inflammation by decreasing P38 phosphorylation and down-regulating NF-κB. These results demonstrate that L. plantarum C88 efficiently protects against alcoholic chronic liver injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 97-104
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 97-104
نویسندگان
Lei Zhao, Yu Jiang, Yuxin Ni, Tianzhu Zhang, Cuicui Duan, Cheng Huang, Yujuan Zhao, Lei Gao, Shengyu Li,