کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137269 | 1494531 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transport of angiotensin converting enzyme and renin dual inhibitory peptides LY, RALP and TF across Caco-2 cell monolayers
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transport of angiotensin converting enzyme and renin dual inhibitory peptides LY, RALP and TF across Caco-2 cell monolayers Transport of angiotensin converting enzyme and renin dual inhibitory peptides LY, RALP and TF across Caco-2 cell monolayers](/preview/png/5137269.png)
چکیده انگلیسی
In order for peptides to exert physiological effects, intact transportation or absorption of their degradation fragments with bioactive potency is required. In this study, Caco-2 cell model was employed to investigate the stability of ACE- and renin-inhibitory peptides LY, RALP and TF during cellular absorption. Apparent permeability coefficient was 3.49, 0.32, and 0.94Â ÃÂ 10â6Â cm/s for LY, RALP and TF, respectively. LY had the highest infiltration yield of 6.59%, compared to RALP (0.51%) and TF (2.44%) at 180Â min. Peptides collected from the basolateral sides after 180Â min had ACE-inhibitory levels of 33.03%, 14.22% and 14.33% with different initial concentrations for LY (2Â mM), RALP (1Â mM) and TF (3Â mM), respectively. In contrast, renin-inhibitory activities were lower at 9.52% (LY) and 7.37% (RALP) while TF had no inhibition. Thus, dipeptides could be more easily absorbed for controlling hypertension and the fragments of RALP had potential antihypertensive properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 303-314
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 303-314
نویسندگان
Yi-Jie Yang, Hai-Yan He, Feng-Zhang Wang, Xing-Rong Ju, Jian Yuan, Li-Feng Wang, Rotimi E. Aluko, Rong He,