کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137682 | 1494535 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Breadfruit flavonoid derivatives attenuate advanced glycation end products (AGEs)-enhanced colon malignancy in HCT116 cancer cells
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کلمات کلیدی
STAT3NF-κBThe receptor for advanced glycation end productsTHP-1 monocytesJnkRAGEERKAGEsc-Jun N-terminal kinase - C-Jun N-terminal kinaseMAPK - MAPKROS - ROSconditioned media - رسانه های متعلق بهnuclear factor kappa B - فاکتور هسته ای کاپا Bsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3Advanced glycation end products - محصولات نهایی پیشرفته گلیساسیونFlavonoid derivatives - مشتقات فلاونوئیدmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Advanced glycation end products (AGEs)-evoked response is an important event in colon tumorigenesis. The aim of this study was to investigate the effect of flavonoid derivatives isolated from breadfruit Artocarpus communis on AGEs-enhanced colon malignancy in vitro. According to results, glyceraldehyde-derived AGEs (AGE; 200 μg/mL) enhanced the malignancy of HCT116 colon cancer cells; however, treatment with flavonoid derivatives (2â²,4,4â²-trihydroxy-3â²-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone, AC-a; 6-geranyl-4â²,7-dihydroxyflavanone, AC-b; 5â²-geranyl-2â²,4,4â²-trihydroxydihydrochalcone, AC-c; 6-geranyl-4â²,5,7-trihydroxyflavanone, AC-d) inhibited these changes. These flavonoid derivative-induced biological actions are associated with the modulation of MAPK/NF-κB cascades and translocation of STAT3 and β-catenin. Furthermore, we first found that proliferation of HCT116 cells increased when cultured in conditioned media from AGE-induced THP-1 monocytes (AGE-CM), which may be closely related to the action of AGE-stimulated pro-carcinogenic factors in monocytes; however, flavonoid derivatives retarded aforementioned AGE-CM-evoked phenomena. In conclusion, our study first demonstrates that flavonoid derivatives show great potential in ameliorating AGE-enhanced colon malignancy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 31, April 2017, Pages 248-254
Journal: Journal of Functional Foods - Volume 31, April 2017, Pages 248-254
نویسندگان
Jer-An Lin, Chi-Hao Wu, Gow-Chin Yen,