کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5138698 | 1494730 | 2017 | 52 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate](/preview/png/5138698.png)
چکیده انگلیسی
Inhibition of metalloproteases as a therapeutic approach has failed because there is limited knowledge of the degradome of individual proteases as well as the cellular function of cleaved substrates. Using different proteomic techniques, this study uncovered novel substrates that can be modulated by ADAM17 in oral squamous cell carcinoma cell line. Glypican-1 was validated as a novel substrate for ADAM17, with important function in adhesion, proliferation and migration of carcinoma cells. Therefore, this study opens new avenues regarding the proteolysis-mediated function of GPC1 by ADAM17.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 151, 16 January 2017, Pages 53-65
Journal: Journal of Proteomics - Volume 151, 16 January 2017, Pages 53-65
نویسندگان
Rebeca Kawahara, Daniela Campos Granato, Sami Yokoo, Romênia Ramos Domingues, Daniel Maragno Trindade, Adriana Franco Paes Leme,