کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5143261 1496475 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolic network modeling with model organisms
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Metabolic network modeling with model organisms
چکیده انگلیسی
Flux balance analysis (FBA) with genome-scale metabolic network models (GSMNM) allows systems level predictions of metabolism in a variety of organisms. Different types of predictions with different accuracy levels can be made depending on the applied experimental constraints ranging from measurement of exchange fluxes to the integration of gene expression data. Metabolic network modeling with model organisms has pioneered method development in this field. In addition, model organism GSMNMs are useful for basic understanding of metabolism, and in the case of animal models, for the study of metabolic human diseases. Here, we discuss GSMNMs of most highly used model organisms with the emphasis on recent reconstructions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 36, February 2017, Pages 32-39
نویسندگان
, ,