کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5143338 1496473 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets
چکیده انگلیسی
As interest in protein-protein interactions and other previously-undruggable targets increases, medicinal chemists are returning to natural products for design inspiration toward molecules that transcend the paradigm of small molecule drugs. These compounds, especially peptides, often have poor ADME properties and thus require a more nuanced understanding of structure-property relationships to achieve desirable oral bioavailability. Although there have been few clinical successes in this chemical space to date, recent work has identified opportunities to introduce favorable physicochemical properties to peptidic macrocycles that maintain activity and oral bioavailability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 38, June 2017, Pages 141-147
نویسندگان
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