کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5143487 1496567 2017 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel acyclonucleoside analog bearing a 1,2,4-triazole-Schiff base: Synthesis, characterization and analytical studies using square wave-adsorptive stripping voltammetry and HPLC
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Novel acyclonucleoside analog bearing a 1,2,4-triazole-Schiff base: Synthesis, characterization and analytical studies using square wave-adsorptive stripping voltammetry and HPLC
چکیده انگلیسی
New acyclonucleoside analogs tethered by a 1,2,4-triazole scaffold were synthesized through the condensation of 4-amino-5-(2-phenyleth-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (2) with benzaldehyde followed by the alkylation of the resulting Schiff base (3)with 2-bromoethanol, 3-chloropropanol and/or 3-chloropropan-1,2-diol. Voltammetric studies were carried out for the analysis of 1 × 10−6 mol L−1 of the newly synthesized acyclonucleoside analogs (4-6) using square wave-adsorptive stripping voltammetry (SW-AdSV). The sharp voltammetric peak and high reduction current were recorded using a Britton-Robinson B-R pH 10 buffer at Ep = −1250 mV on the hanging mercury drop surface (HMDE) and Ag/AgCl reference electrode. Several experimental conditions were studied, such as the supporting electrolytes, the pH, and the accumulation time, as well as the potential, the scan rate, the frequency and the step potential for 4-benzylideneamino-5-(2-phenyleth-1-yl)-3-[(2,3-dihydroxyprop-1-yl)thio]-1,2,4-triazole (6). The analytical performance of the voltammetric technique was investigated through the analysis of the calibration curve, the detection limit, the recovery and the stability. The voltammetric analytical applications were evaluated by the recovery of compound (6) in the urine and plasma samples. The HPLC technique was also applied for the separation of compound (6) from interference using a C-18 (5 μm) column with UV detection at 254 nm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Taibah University for Science - Volume 11, Issue 5, September 2017, Pages 759-767
نویسندگان
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