New Pt-NNSO core anticancer agents: Structural optimization and investigation of their anticancer activity

New Pt-NNSO coordination core compounds (Pt-NNSO compounds) generate a mixture of Pt-G mono- and Pt-GG diadducts with DNA and they are minimally affected by resistance. The lack of resistance is likely due to their low reactivity with thiol biomolecules and their ability to inhibit autophagy.49