Improve the anticancer potency of the platinum(II) complexes through functionalized leaving group

Two platinum(II) complexes with 3,3-dimethoxycyclobutane-1,1-dicarboxylate as a leaving group were designed and synthesized. The different functionalized leaving groups resulted in quite different biomolecular binding rates and lead to the conspicuous difference of the biological features of the platinum(II) complexes.104