Zn(II) - pramlintide: Stability, binding sites and unexpected aggregation

An antidiabetic drug which mimics amylin, pramlintide, forms stable complexes with Zn(II). The metal binds to the imidazole of His18 and the amine group of Lys1. The initially well-soluble Zn(II)-pramlintide complex forms fibrillar aggregates after a lag-time of 20 h.161