Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties

The acetylated form of heptapeptide Semax is an analog of the adrenocorticotropic hormone ACTH(4-10) fragment. This study shows the importance of N-terminus on copper and zinc binding ability and on the protective activity of this peptide against metal induced cytotoxicity.142