The in vitro antitumor activity of oligonuclear polypyridyl rhodium and iridium complexes against cancer cells and human pathogens

Oligonuclear polypyridyl half sandwich rhodium and iridium complexes have been synthesized and characterized. Their activity over four pathogenic bacteria and four cancer lines has been assessed. Antibacterial activity has been estimated against four bacteria viz. Staphylococcus aureus MTCC96; Escherichia coli MTCC739; Klebsiella pneumonia MTCC2653 and Pseuedomonas aeruginosa MTCC2453. Antiproliferative activity has been evaluated against four cancer cell lines viz. B16F10 (Mouse melanoma carcinoma), THP-1 (Human acute monocytic leukemia), PC3 (Human prostate carcinoma) and SK-OV-3 (Human ovarian carcinoma).