Synthesis and antitumor activity evaluation of quinazoline derivatives bearing piperazine-1-carbodithioate moiety at C4-position

4-Quinazolinylpiperazine-1-carbodithioates 8a-q and 9a-i were synthesized. Most of them exhibited promising cytotoxicity, and 8n induced a dose-dependent G0/G1 phase arrest in HCT-116 cells.51