کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5156556 1500582 2017 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and fabrication of a chitosan hydrogel with gradient structures via a step-by-step cross-linking process
ترجمه فارسی عنوان
طراحی و ساخت یک هیدروژل کیتوزان با سازه های شیب دار از طریق یک فرایند پیوند گام به گام
کلمات کلیدی
کیتوزان، هیدروژل، ساختار گرادیان، پیوند گام به گام،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
The development of scaffolds to mimic the gradient structure of natural tissue is an important consideration for effective tissue engineering. In the present study, a physical cross-linking chitosan hydrogel with gradient structures was fabricated via a step-by-step cross-linking process using sodium tripolyphosphate and sodium hydroxide as sequential cross-linkers. Chitosan hydrogels with different structures (single, double, and triple layers) were prepared by modifying the gelling process. The properties of the hydrogels were further adjusted by varying the gelling conditions, such as gelling time, pH, and composition of the crosslinking solution. Slight cytotoxicity was showed in MTT assay for hydrogels with uncross-linking chitosan solution and non-cytotoxicity was showed for other hydrogels. The results suggest that step-by-step cross-linking represents a practicable method to fabricate scaffolds with gradient structures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 176, 15 November 2017, Pages 195-202
نویسندگان
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