کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156767 | 1500580 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure and in vitro anticancer activity of sulfated O-polysaccharide from marine bacterium Poseidonocella pacifica KMM 9010T
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We presented the structure of the sulfated polysaccharide moiety and anticancer activity in vitro of the Ð-deacylated lipopolysaccharide (DPS) isolated from the marine bacterium Poseidonocella pacifica KMM 9010T. The structure of O-polysaccharide was investigated by chemical methods along with 1H and 13C NMR spectroscopy. The O-polysaccharide was built up of sulfated disaccharide repeating units consisted of d-rhamnose (d-RhaÑ) and 3-deoxy-d-manno-oct-2-ulosonic acid (Kdop): â7)-β-KdoÑ4Ac5S-(2â3)-β-d-RhaÑ2S-(1â. We demonstrated that the DPS from P. pacifica KMM 9010T non-toxic for normal mouse epidermal cells (JB6 Cl41 cell line) and inhibited colony formation of human colorectal carcinoma HT-29, breast adenocarcinoma MCF-7 and melanoma SK-MEL-5 cells in a dose-dependent manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 178, 15 December 2017, Pages 406-411
Journal: Carbohydrate Polymers - Volume 178, 15 December 2017, Pages 406-411
نویسندگان
Maxim S. Kokoulin, Alexandra S. Kuzmich, Anatoly I. Kalinovsky, Eugene S. Rubtsov, Lyudmila A. Romanenko, Valery V. Mikhailov, Nadezhda A. Komandrova,