کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5156933 1500593 2017 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Submicrometric hypromellose acetate succinate particles as carrier for soy isoflavones extract with improved skin penetration performance
ترجمه فارسی عنوان
ذرات سوکسینات استات هیپرومولوز ساب میکرولیس به عنوان حامل برای عصاره ایزوفلاون سویا با عملکرد نفوذ پوستی بهبود یافته
کلمات کلیدی
هیپرومولوز استات سوکسینات، عصاره ایزوفلاون سویا، ذرات زیرمیکرومتری، خشک کن نانو اسپری، نفوذ پوستی پیشرفته،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
In this study, hypromellose acetate succinate (HPMCAS) stable submicronic particles loaded with a soy isoflavones extract have been obtained by nano spray drying technology. HPMCAS has been used as excipient able to increase both stability and supersaturation levels of the active ingredients hence able to enhance skin penetration performance of genistein and daidzein. The influence of polymer/extract ratio as other process variables, on particle size, morphology and permeation performance, have been investigated. Particles in submicronic range (mean size around 550 nm) and narrow size distribution with high encapsulation efficiency (up to 86%) were obtained. HPMCAS was able to improve amorphization of genistein during the atomization process and avoid recrystallization during storage, even in harsh environmental condition. Moreover, the enhanced affinity of the optimized formulations with aqueous media, strongly increased isoflavones penetration through membrane with diffusive properties well-correlated to human skin, up to 10-fold higher than pure soy isoflavones extract raw material.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 165, 1 June 2017, Pages 22-29
نویسندگان
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