کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157237 | 1500598 | 2017 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a nanoparticle system based on a fructose polymer: Stability and drug release studies
ترجمه فارسی عنوان
توسعه یک سیستم نانوذرات مبتنی بر پلیمر فروکتوز: مطالعات استقراضی و آزادی دارویی
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
New drug delivery systems (DDSs) with levan or its carboxymethylated form, as carriers, and 5-fluorouracil as a drug, are produced in this work. Levan is obtained after cultivating A. nectaris and polymer nanoparticles are created in water by a self-assembled process. The effect of pH and the ionic strength on polymer nanoparticles aggregation is studied. Basic pHs produces a particle size between 300 and 400Â nm with a Z-potential around â20Â mV because a basic medium promotes repulsion forces. DDSs of 300-400Â nm and a Z-potential about â25Â mV are prepared by taking advantage of the amphiphilic properties of the levan. The drug is bound to either levan or carboxymethyllevan surfaces by electrostatic interactions, obtaining the best results at basic pHs. 45-70% of the drug is released from the levan in 23Â h depending on the pH preparation, whereas only a low percentage of the drug is released from the carboxymethyllevan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 160, 15 March 2017, Pages 26-33
Journal: Carbohydrate Polymers - Volume 160, 15 March 2017, Pages 26-33
نویسندگان
Antonio Tabernero, Álvaro González-Garcinuño, José Mª Sánchez-Álvarez, Miguel A. Galán, Eva M. MartÃn del Valle,