کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157242 | 1500598 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-anticoagulant effects of low molecular weight heparins in inflammatory disorders: A review
ترجمه فارسی عنوان
اثرات ضد انعقاد کننده هپارین کم مولکولی در اختلالات التهابی: بررسی
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کلمات کلیدی
غیر انعقاد هپارین های مولکولی کم، التهاب هپارین
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Low molecular weight heparins (LMWHs) are produced by chemical or enzymatic depolymerization of unfractionated heparin (UFH). Besides their well-known anticoagulant effects, LMWHs have also been reported to exhibit numerous anti-inflammatory properties. Previous studies have, however, shown that different production processes result in unique structural characteristics of LMWHs. The structural variations may help explain the different therapeutic spectrums in disease treatment for non-anticoagulant effects. In the present review, we summarize major advances in understanding and exploiting the anti-inflammatory disorder activities of LMWHs, based on mechanistic studies, preclinical experiments and clinical trials. We highlight differences in these activities of commercially available LMWHs produced using different manufacturing processes. We stress the importance of structure-activity relationship (SAR) studies on the non-anticoagulant effects of LMWHs and discuss strategies for exploring new clinical indications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 160, 15 March 2017, Pages 71-81
Journal: Carbohydrate Polymers - Volume 160, 15 March 2017, Pages 71-81
نویسندگان
Yishu Yan, Yang Ji, Nan Su, Xiang Mei, Yi Wang, Shanshan Du, Wenming Zhu, Chong Zhang, Yuan Lu, Xin-Hui Xing,