Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone

Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.