کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157398 | 1500585 | 2017 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fabrication and characterization of hollow starch nanoparticles by gelation process for drug delivery application
ترجمه فارسی عنوان
ساخت و مشخص نمودن نانوذرات نشاسته توخالی توسط روش ژل سازی برای کاربرد دارو
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
پوشش نشاسته، نانوذرات توخالی، ژل، کربنات کلسیم، بسته بندی دارو،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Hollow nanoparticles (HNPs) have been widely regarded as controlled drug carriers owing to their advantages, such as high drug-loading efficiency and superior control over drug delivery and release. In this study, a facile and efficient strategy has been exploited for preparation of hollow starch nanoparticles (HSNPs) via a sacrificial hard-template process using gelled starch as the shell. These nanocapsules have been characterized through various techniques, including transmission electron microscopy, differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared spectroscopy. The HSNPs have diameters ranging from 30 nm to 300 nm, with shell thickness of 5-10 nm. X-ray diffraction analysis has revealed that HSNPs exhibit B + V type diffraction peaks with a relative crystallinity of 34.2%. Doxorubicin hydrochloride (DOX·HCl) was readily encased in the nanocarriers with a high loading efficiency (97.56%) and a high loading content (37.12%). In addition, no cytotoxicity for normal liver cells was found in HSNPs. However, DOX·HCl-loaded HSNPs exhibited clear cytotoxicity for liver hepatocellular cells. Thus, the hollow starch nanoparticles form a highly promising platform for cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 223-232
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 223-232
نویسندگان
Jie Yang, Fang Li, Man Li, Shuangling Zhang, Jing Liu, Caifeng Liang, Qingjie Sun, Liu Xiong,