کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157409 | 1500585 | 2017 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Macromolecular properties and hypolipidemic effects of four sulfated polysaccharides from sea cucumbers
ترجمه فارسی عنوان
خواص کربوهیدرات و اثرات هیپولیپیدمی چهار پلی ساکارید سولفات شده از خیار دریایی
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کلمات کلیدی
پلی ساکارید سولفات از خیار دریایی، پیوند زنجیره ای، فعالیت ضد هیپرلیپیدمی ساختار-عملکرد رابطه،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The present study investigates the relationship between the high-order structure and hypolipidemic activity of four well-defined sulfated fucans from sea cucumber. The chain conformation, determined by a combination of AFM and SEC-MALLS-RI, indicate that fucosylated chondroitin sulfate (fCS) from Pearsonothuria graeffei (fCS-Pg) and Isostichopus badionotus (fCS-Ib), and fucoidan from P.graeffei (fuc-Pg) were assigned as a random coil conformation with polysaccharide chain outstretched, while I. badionotus (fuc-Ib) was assigned as a spherical conformation and exhibited high viscosity. Fuc-Pg and fuc-Ib with higher molecular weights had a greater impact in inhibiting pancreatic lipase activity in vitro. However, fCS-Pg, fCS-Ib and fuc-Pg with random linear conformation exhibited excellent hypolipidemic activity in Sprague-Dawley rats (SD rats) fed on high-fat diet (HFD), whereas fuc-Ib showed only a modest effect. Our results indicate that structural characteristics, including side branch and sulfation pattern can affect the chain conformation of polysaccharides, which determine their physicochemical properties and hypolipidemic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 330-337
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 330-337
نویسندگان
Shan Li, Junhui Li, Zijian Zhi, Chaoyang Wei, Wenjun Wang, Tian Ding, Xingqian Ye, Yaqin Hu, Robert J. Linhardt, Shiguo Chen,