کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157437 | 1500585 | 2017 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and characterization of mucosal adhesive and two-step drug releasing cetirizine-chitosan nanoparticle
ترجمه فارسی عنوان
آماده سازی و مشخص کردن خواص چسبنده مخاطی و دو مرحله ای نانوذرات سیتیزین- کیتوزان آزاد
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
To develop a functional nanosized mucosal drug delivery system, a series of amphiphilic cetirizine-chitosan polymer (CTZ-CSs) were constructed. CTZ-CSs could self-assemble into nanoparticles (NPs) which gradually evolved from irregular aggregates to spherical particles with an increasing substitution degree (DS) in CTZ group. The average particle size of CTZ-CSs-NPs with nano ZS90 Zetasizer varied from 153.92Â nm to 184.48Â nm and their zeta potential varied between +19.14Â mV and +22.93Â mV. Biocompatibility assay exhibited CTZ-CS-NPs had few adverse effects within a certain concentration range. Cetirizine dihydrochloride(CedH):CTZ-CS-NPs displayed burst and sustained drug release profiles in the presence of lysozyme. CedH showed a burst release during the first 6Â h, after which the release rate slowed down significantly. The release of CedH totally sustained for 72Â h. Ex vivo mucosal adhesion indicated CedH:CTZ-CS-NPs were able to prolong the residence time in the entire small intestine mucosa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 600-609
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 600-609
نویسندگان
Xiaoping Yu, Yuzhi Mu, Mengxue Xu, Guixue Xia, Juan Wang, Ya Liu, Xiguang Chen,