A unique indolizinium alkaloid streptopertusacin A and bioactive bafilomycins from marine-derived Streptomyces sp. HZP-2216E

A unique indolizinium alkaloid streptopertusacin A (1) existing as a zwitterion and two previously undescribed bafilomycin analogues of 21,22-en-bafilomycin D (2) and 21,22-en-9-hydroxybafilomycin D (3) were isolated from a culture of seaweed-derived Streptomyces sp. HZP-2216E. Bafilomycins 2 and 3 had potent activities in inhibiting the proliferation of glioma cells and the growth of methicillin-resistant Staphylococcus aureus.519