Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum

Six new ergostane derivatives, together with two known compounds, were isolated from Antrocaryon klaineanum. The compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum. Compounds 2, 3, and 8 showed potent activity.