Novel stilbenoids, including cannabispiradienone glycosides, from Tragopogon tommasinii (Asteraceae, Cichorieae) and their potential anti-inflammatory activity

Aerial parts of Tragopogon tommasinii Sch.Bip. (Asteraceae, Cichorieae) yielded 21 natural compounds, including seven new stilbenoids; three simple bibenzyls, two benzylphthalides, and two glucopyranosyl-de-methoxy-canna-bispiradienoides. Structures were established by HR mass spectrometry and extensive 1D and 2D NMR spectroscopy. Bioactivity of new compounds on human neutrophils and on their release of IL-8, IL-1β TNF-α, and MMP-9 and on the surface expression of TLR-4 in particular was investigated.