Hypoglycemic and antihyperglycemic effects of phytopreparations and limonoids from Swietenia humilis

Limonoids 2-hydroxy-destigloyl-6-deoxyswietenine acetate, humulin B, methyl-2-hydroxy-3-β-isobutyroxy-1-oxomeliac-8(30)-enate, methyl-2-hydroxy-3-β-tigloyloxy-1-oxomeliac-8(30)-enate, humilinolide G, humilinolide C, methyl-2-hydroxy-3-β-isobutyoyl-8α,30α-epoxy-1-oxo-meliacate, and humilinolide H were isolated from Swietenia humilis seeds. Four of these compounds exhibited antihyperglycemic action when tested in hyperglycemic mice.