Natural daucane esters induces apoptosis in leukaemic cells through ROS production

DE-17 induced apoptosis in SEM and Jurkat cell lines. ROS induction, a decreased mRNA expression of antioxidant enzymes and intracellular GSH content were detected in treated cells. DE-17 induced mitochondrial depolarization, and caspase-3 and -9 activation. Daucane esters induces apoptotic cell death through a ROS-mediated mechanism in human leukemia cells.75