Furofuran lignans display schistosomicidal and trypanocidal activities

This paper describes schistosomicidal, trypanocidal, and leishmanicidal activities of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2. Antiparasitic activities were evaluated in vitro against Schistosoma mansoni adult worms, trypomastigote and amastigotes forms of Trypanosoma cruzi, and promastigote forms of Leishmania amazonensis.