Limonoids from the fruits of Melia toosendan and their NF-κB modulating activities

Eight ring C-seco and ring-intact limonoids (1-8), along with 25 known limonoids were isolated from the fruits of Melia toosendan (Meliaceae). Biological assay showed that limonoids from M. toosendan enhance or inhibit the TNFα-induced NF-κB activation.