An antibacterial metabolite from Lasiodiplodia pseudotheobromae F2

Sulfureous diketopiperazines, designated as lasiodiplines A-F (1-6), were isolated from a culture of Lasiodiplodia pseudotheobromae F2. Lasiodipline E (5) was demonstrated to be antibacterial against the clinical strains examined. Compounds 4 and 6 exemplify two unusual architectures of natural cyclodipeptides, signifying the unique biochemical characteristics of the producing fungus.