Acylated oleanane-type saponins from Ganophyllum giganteum

Five oleanane-type saponins (1-5) were isolated from the barks of Ganophyllum giganteum. The fucopyranosyl moiety of the oligosaccharidic chain of two saponins possessed an unusual substitution of the C-4 position by a C10 ester group formed by two symmetrical C5 nilic acid. From a chemotaxonomic point of view, their structures are in accordance with the previous saponins isolated from the Doratoxyleae tribe of the Sapindaceae family. Their cytotoxicity and anti-inflammatory activity were also evaluated.