1,5-Diphenylpent-3-en-1-ynes and methyl naphthalene carboxylates from Lawsonia inermis and their anti-inflammatory activity

► Henna is a well-known herb used for centuries for hair care and healing. ► Henna is prescribed for skin diseases due to its anti-inflammatory activity. ► Three 1,5-diphenylpent-3-en-1-ynes and three methyl naphthalene carboxylates were isolated from henna. ► Two of the isolated compounds exhibited potent anti-inflammatory activity.