Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement

► Cecropia pachystachya contains anti-leishmanial flavonoids. ► Flavonoids altered mitochondrial DNA arrangements. ► Flavonoids are strong inhibitors of arginase. ► Orientin (luteolin-8-C-glucoside) show an IC50 of 16 μM for arginase inhibition.