Antiproliferative activity and absolute configuration of zonaquinone acetate from the Jamaican alga Stypopodium zonale

► Compound zonaquinone acetate was isolated from the Jamaican brown alga Stypopodium zonale. ► Absolute configuration of zonaquinone acetate was established by VCD measurements. ► Cytotoxic activity was reported in vitro for zonaquinone acetate against breast cancer and colon cancer cell lines. ► Bioactivity of zonaquinone acetate compared favorably with the standard treatments tamoxifen and fluorouracil.