Bioguided fractionation and isolation of natural inhibitors of advanced glycation end-products (AGEs) from Calophyllum flavoramulum

► Extracts from Clusiaceae/Calophyllaceae were tested for their antiAGEs potential. ► Calophyllum flavoramulum MeOH leaf extract was selected. ► Its bioguided fractionation led to identify 1 and 2 as very potent AGEs inhibitors. ► Two new products 3 and 8 were also isolated and described.