Phloroglucinol derivatives from Hypericum empetrifolium with antiproliferative activity on endothelial cells

► We isolated five phloroglucinol derivatives from Hypericum empetrifolium. ► We applied a 1H NMR guided approach. ► We found a rare monoterpenoid substitution of the phloroglucinols. ► We found significant inhibition of cell proliferation in endothelial cells.