A folate independent role for cytosolic HPPK/DHPS upon stress in Arabidopsis thaliana

► Cytosolic HPPK/DHPS has a possible folate-independent role in Arabidopsis. ► Gene over-expression resulted in higher germination rate under stress conditions confirming its role in stress tolerance. ► Cytosolic HPPK/DHPS expression during stress suggests a potential role for pterins in plant stress response.